Bolus (80 u/kg)
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Initial Infusion (18 u/kg)
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| Monitoring | ||||||||
|---|---|---|---|---|---|---|---|---|
| aPTT (s) | Anti-Xa | Instructions | Bolus | u/kg | u | Infusion Rate | u/kg | u/hr |
| <41 | <0.15 | Bolus, increase rate | Yes | 80 | -- | Increase | 4 | -- |
| 41-60 | 0.15-0.29 | Bolus, increase rate | Yes | 40 | -- | Increase | 2 | -- |
| 61-112 | 0.30-0.70 | NO CHANGE | ||||||
| 113-150 | 0.71-1.00 | Decrease Rate | No | Decrease | 2 | -- | ||
| 151-250 | 1.01-1.10 | Stop 1 hr, reduce rate | No | Decrease | 3 | -- | ||
| >250 | >1.10 | Stop heparin. STAT aPTT or anti-Xa in 1 hour. | ||||||